Advise individuals not to adjust the dose of acetaminophen and codeine phosphate tablets with out consulting a medical doctor or other Health care Specialist.

Two-12 months carcinogenicity experiments are already done in F344/N rats and B6C3F1 mice. There was no evidence of carcinogenicity in male and feminine rats, respectively, at dietary doses as many as 70 and eighty mg/kg/day of codeine sulfate (around two periods the maximum suggested each day dose of 360 mg/working day for adults on the mg/m2 basis) for 2 decades.

The chance of acute liver failure is greater in people today with fundamental liver ailment and in individuals who ingest alcohol even though having acetaminophen.

No nonclinical fertility research happen to be performed with codeine or The mixture of codeine and acetaminophen.

When discontinuing or decreasing opioid doses in sufferers who are receiving therapy for an prolonged interval and/or at better doses for Serious suffering, a multimodal method of pain administration might optimize the remedy of Long-term pain, in addition to aid Along with the thriving tapering of the opioid analgesic.

Immediately after stopping use of a CYP2D6 inhibitor, take into account lowering the acetaminophen and codeine phosphate tablets and Appraise the patient for indicators and indicators of respiratory despair or sedation.

If one particular isn't out there, you'll be able to get rid of Acetaminophen and Codeine Phosphate Tablets, USP by mixing the item with Filth, cat litter, or coffee grounds; positioning the mixture inside of a sealed plastic bag, and throwing the bag in the trash.

Parenteral drug abuse is usually related to transmission of infectious diseases which include hepatitis and HIV.

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seventy eight times the MHDD (depending on a human body area click here comparison) and there was a discount in the quantity of mating pairs producing a fifth litter at this dose, suggesting the prospective for cumulative toxicity with Long-term administration of acetaminophen near the upper Restrict of daily dosing.

Possibility of Medication Glitches: Guarantee accuracy when prescribing, dispensing, and administering the oral solution; dosing faults as a consequence of confusion involving mg and mL, and various codeine methods of various concentrations can result in accidental overdose and Dying.

In One more study an individual 100 mg/kg subcutaneous dose of codeine administered to pregnant mice reportedly website resulted in delayed ossification during the offspring.

Like other narcotic medicines, codeine can sluggish your respiration. Demise could happen check here if breathing gets to be too weak.

Notify people that more info acetaminophen and codeine phosphate tablets might impair the psychological more info and/or Actual physical talents necessary for that performance of probably dangerous duties which include driving an auto or working equipment and to avoid this kind of responsibilities when using this item, until they understand how they'll respond towards the medication.